Nicotine Addiction

(Tobacco Use Disorder; Smoking Addiction)

Overview

Definition

Definition

Nicotine addiction is when a person becomes dependent on nicotine. Being dependent means there is a physical change in how your body reacts to a substance. Your body will also have a reaction when you stop using the substance. Nicotine can be found in tobacco products such as cigarettes, snuff, chewing tobacco, cigars, or pipes.

Tobacco use is also associated with several serious health conditions, such as:

Throat Cancer

Copyright © Nucleus Medical Media, Inc.

Nicotine addition can be treated, often with a combination of therapies.

Causes

Causes

Nicotine acts on the brain’s chemistry. It creates feelings of pleasure. However, the effects go away within a few minutes. Users will need to continue using nicotine to keep the good feelings going. This cycle can lead to addiction.

Risk Factors

Risk Factors

Anyone who uses nicotine products can become addicted to the substance.

The risk may increased with:

  • Family history or exposure to smoking
  • Exposure to smoking in movies
  • Depression
  • Victims of bullying

Symptoms

Symptoms

Symptoms develop when nicotine is not being used, also known as withdrawal. Symptoms of withdrawal include:

  • Irritability
  • Craving
  • Nervousness
  • Headache
  • Thinking and attention problems
  • Trouble sleeping
  • Increased appetite

Diagnosis

Diagnosis

Your doctor will ask about your symptoms, medical and smoking history. A physical exam will be done.

Breathing tests may also be done to see how well your lungs are working.

Your doctor may monitor your nicotine use by checking a cotinine level in your saliva or blood.

Treatment

Treatment

Talk with your doctor about the best treatment plan for you. Treatment may involve one or more therapies. Options include:

Nicotine Replacement Therapy (NRT)

NRT relieves withdrawal symptoms. NRT products:

  • Nicotine gum
  • Lozenges
  • Nasal sprays
  • Patches
  • Inhalers

The chance of abusing these products is low since NRT does not create “feel good” feelings.

NRT may help you to:

  • Avoid smoking
  • Reduce the amount of tobacco you use
  • Quit and stay smoke-free

Electronic Cigarettes

Electronic cigarettes (e-cigarettes) turn liquid nicotine into a vapor that can be puffed. Some smokers have used e-cigarettes to help them quit. Right now, there is conflicting evidence on whether or not this is the case.

However, one promising review of two studies showed the six-month quit rate for e-cigarettes was higher than a non-nicotine placebo. In one of the studies, e-cigarettes were as effective as nicotine patches after six months. Currently, the US Food and Drug Administration (FDA), along with several major anti-smoking organizations, have determined that there has not been enough research on e-cigarettes to make any claims about their safety or effectiveness in helping people quit smoking.

Behavioral Therapy

Behavioral therapies include:

  • Counseling
  • Group behavior therapy
  • Telephone quit lines, cell phone programs, and text messaging programs
  • Internet and computer-based programs
  • Self-help classes and manuals
  • Cognitive behavioral therapy

Medication

Some antidepressants and nicotine partial agonists may help you quit. Other medications may help ease withdrawal symptoms or block the effects of nicotine if you start smoking again.

Prevention

Prevention

The best prevention is to never use tobacco products. Try to avoid places where people are smoking.

RESOURCES:

American Cancer Society http://www.cancer.org

American Lung Association Freedom From Smoking http://www.ffsonline.org/

Smokefree Telephone: 1-800-QUITNOW http://www.smokefree.gov

CANADIAN RESOURCES:

Canadian Cancer Society http://www.cancer.ca

The Lung Association http://www.lung.ca/home-accueil_e.php

References:

Kenfield SA, Stampfer MJ, Rosner BA, Colditz GA. Smoking and smoking cessation in relation to mortality in women. JAMA. 2008;299:2037-2047.

Questions about smoking, tobacco, and health. American Cancer Society website. Available at:
http://www.cancer.org/acs/groups/cid/documents/webcontent/002974-pdf.pdf
Updated January 17, 2013. Accessed March 11, 2013.

Tobacco addiction. National Institute on Drug Abuse website. Available at:
http://www.drugabuse.gov/publications/research-reports/tobacco/letter-director
Updated July 12, 2012. Accessed March 11, 2013..

Tobacco use disorder. DynaMed website. Available at:
http://www.ebscohost.com/dynamed
Updated December 16, 2013. Accessed February 24, 2014.

Tobacco use disorder. PEMSoft at EBSCO DynaMed website. Available at:
http://www.ebscohost.com/dynamed
Updated February 19, 2013. Accessed March 11, 2013.

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9/24/2007 DynaMed’s Systematic Literature Surveillance
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3/25/2008 DynaMed’s Systematic Literature Surveillance
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10/14/2008 DynaMed’s Systematic Literature Surveillance
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Shiffman S, Ferguson SG. Nicotine patch therapy prior to quitting smoking: a meta-analysis. Addiction. 2008;103:557-563.

12/16/2008 DynaMed’s Systematic Literature Surveillance
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Eisenberg MJ, Filion KB, et al. Pharmacotherapies for smoking cessation: a meta-analysis of randomized controlled trials. CMAJ. 2008;179:135-144.

2/5/2009 DynaMed’s Systematic Literature Surveillance
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Cochran CJ, Gallicchio L, et al. Cigarette smoking, androgen levels, and hot flushes in midlife women. Obstet Gynecol. 2008;112:1037-1044.

2/17/2009 DynaMed’s Systematic Literature Surveillance
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Stead LF, Lancaster T. Group behaviour therapy programmes for smoking cessation. Cochrane Database Syst Rev. 2009;(1):CD001007.

7/6/2009 DynaMed’s Systematic Literature Surveillance
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Myung SK, McDonnell DD, et al. Effects of web- and computer-based smoking cessation programs: Meta-analysis of randomized controlled trials. Arch Intern Med. 2009;169:929-937.

7/21/2009 DynaMed’s Systematic Literature Surveillance
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11/13/2009 DynaMed’s Systematic Literature Surveillance
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Piper ME, Smith SS, et al. A randomized placebo-controlled clinical trial of 5 smoking cessation pharmacotherapies. Arch Gen Psychiatry. 2009;66(11):1253-1262.

12/21/2009 DynaMed’s Systematic Literature Surveillance
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Whittaker R, Borland R, et al. Mobile phone-based interventions for smoking cessation. Cochrane Database Syst Rev. 2009;(4):CD006611.

11/30/2010 DynaMed’s Systematic Literature Surveillance
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Rusanen M, Kivipelto M, et al. Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Arch Intern Med. 2011;171(4):333-339.

4/29/2011 DynaMed’s Systematic Literature Surveillance
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Mills E, Eyawo O, et al. Smoking cessation reduces postoperative complications: A systematic review and meta-analysis. Am J Med. 2011;124(2):144-154.e8.

6/24/2011 DynaMed’s Systematic Literature Surveillance
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Leonardi-Bee J, Britton J, et al. Secondhand smoke and adverse fetal outcomes in nonsmoking pregnant women: a meta-analysis. Pediatrics. 2011;127(4):734-741.

9/9/2013 DynaMed’s Systematic Literature Surveillance
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Bullen C, Howe C, et al. Electronic cigarettes for smoking cessation: A randomised controlled trial. Lancet. 2013;382(9905):1629-1637.

3/19/2015 DynaMed’s Systematic Literature Surveillance
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McRobbie H, Bullen C, et al. Electronic cigarettes for smoking cessation and reduction. Cochrane Database Syst Rev. 2014;12:CD010216.

Last reviewed January 2015 by Michael Woods, MD
Last Updated: 3/19/2015

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